ea0059oc3.5 | Obesity & diabetes | SFEBES2018
Ratnasabapathy Risheka
, Ma Yue
, Izzi-Engbeaya Chioma
, Nguyen-Tu Marie-Sophie
, Richardson Errol
, Hussain Sufyan
, De Backer Ivan
, Holton Christopher
, Norton Mariana
, Carrat Gaelle
, Schwappach Blanche
, Rutter Guy A
, Dhillo Waljit S
, Gardiner James V
As the nation gets fatter, the incidence of diabetes is also rising. The brain is now emerging as a critical mediator of blood sugar control, re-directing focus away from the traditional pancreas-centred model. The enzyme glucokinase (GK) acts as a glucose sensor in many tissues including glucose-sensitive neurones within the hypothalamic arcuate nucleus. However, the role of GK here is unclear. We investigated the role of arcuate GK in glucose homeostasis in both healthy and ...